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乙型肝炎病毒(HBV)是一种高度变异的病毒,近年来随着筛选供血员措施和乙肝疫苗预防接种计划的实施,出现了新的临床和流行病学问题,如HBsAg(-)HBV感染,HBsAg和抗HBs共存,抗HBs阳性慢性活动性肝炎等现象,用聚合酶链反应(PCR)和DNA测序技术,从病毒变异角度探讨上述新问题,研究病毒变异后抗原性和致病性的改变以及临床上出现的不同疾病谱的关系,对现行供血筛检方案、检测试剂、乙肝疫苗和抗病毒药物的改进都将可能产生影响,本文就HBV基因结构特点以及变异后的临床意义综述如下。
Hepatitis B virus (HBV) is a highly variant virus that has emerged in recent years with new clinical and epidemiological issues such as HBsAg (-) HBV infection, with screening donor programs and hepatitis B vaccination programs , HBsAg and anti-HBs coexistence, anti-HBs positive chronic active hepatitis phenomenon, using polymerase chain reaction (PCR) and DNA sequencing technology, from the perspective of the virus mutation to explore these new issues, research antigenicity and pathogenic Changes and clinical manifestations of different disease spectrum, the current blood supply screening programs, testing reagents, hepatitis B vaccine and antiviral drugs will likely have an impact on the improvement of HBV gene structure characteristics and the clinical significance of the mutation are summarized below .