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目的:观察VOF方案(替尼泊苷+奥沙利铂+5-氟尿嘧啶)用于胃癌患者术后辅助化疗的治疗效果及不良反应。方法:胃癌根治术后应用VOF方案化疗者45例为VOF组,仅行根治术的41例胃癌患者为单纯手术组,比较2组生存率、中位总生存时间和无病生存时间以及药物不良反应。结果:VOF组和单纯手术组的1,3,5 a总生存率分别为88.9%,62.2%,37.8%和70.7%,46.3%,22.0%,中位总生存时间分别为52.8个月和24.9个月(P<0.05);1,3,5 a无病生存率分别为77.8%,57.8%,31.1%和58.5%,34.1%,17.1%,中位无病生存时间分别为44.8个月和21.6个月(P<0.05);VOF组患者白细胞计数减少、厌食及恶心、呕吐发生率分别为84.4%,68.9%,62.2%。结论:对胃癌患者术后应用VOF方案辅助化疗可明显提高术后生存率及无病生存时间,不良反应可耐受。
Objective: To observe the therapeutic effect and adverse reactions of VOF regimen (teniposide + oxaliplatin + 5-fluorouracil) for postoperative adjuvant chemotherapy in patients with gastric cancer. Methods: Forty-five patients who underwent VOF regimen after radical resection of gastric cancer were treated with VOF. 41 patients with gastric cancer undergoing radical operation were treated with simple operation. Survival, median overall survival and disease-free survival were compared between the two groups reaction. Results: The overall 1,3,5-year survival rates of VOF group and surgery group were 88.9%, 62.2%, 37.8% and 70.7%, 46.3% and 22.0%, respectively. The median overall survival time was 52.8 months and 24.9 (P <0.05). The 1, 3 and 5 year disease-free survival rates were 77.8%, 57.8%, 31.1% and 58.5%, 34.1% and 17.1% respectively. The median duration of disease-free survival was 44.8 months 21.6 months (P <0.05). The white blood cell count, the anorexia, nausea and vomiting in the VOF group were 84.4%, 68.9% and 62.2% respectively. Conclusion: The postoperative VOF regimen adjuvant chemotherapy for gastric cancer patients can significantly improve postoperative survival and disease-free survival time, adverse reactions can be tolerated.