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目的分析Notch4的表达与乳腺癌临床病理学特征的关系。方法收集送检的乳腺癌患者85例乳腺组织标本,经免疫组化后按Notch4表达情况分为低表达组37例和高表达组48例,比较2组乳腺癌标本病理学特征。结果 Notch4在乳腺癌组织的表达增高,主要表达于癌细胞胞浆;Notch4低表达组标本的肿瘤直径、肿瘤分期、组织学分级、淋巴结转移与Notch4高表达组比较差异均有统计学意义(P<0.01)。结论 Notch4表达与肿瘤直径、肿瘤分期与淋巴结转移等指标有关,有借鉴意义。
Objective To analyze the relationship between Notch4 expression and clinicopathological characteristics of breast cancer. Methods Totally 85 breast cancer samples collected from breast cancer patients were collected and divided into low expression group (37 cases) and high expression group (48 cases) according to the expression of Notch4 after immunohistochemistry. The pathological features of the two groups were compared. Results The expression of Notch4 in breast cancer tissues was increased, which was mainly expressed in the cytoplasm of cancer cells. The expression of Notch4 in low expression of Notch4 tumor tissues, tumor stage, histological grade, lymph node metastasis and Notch4 overexpression group were significantly different (P <0.01). Conclusion The expression of Notch4 is correlated with tumor diameter, tumor stage and lymph node metastasis.