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对２６例肝硬化、５例非肝硬化性肝胆疾病和１０例非肝胆疾病（对照组）患者，采用~（９９ｍ）ＴｃＭＩＢＩ直肠给药，测定心／肝核素显像比值（Ｈ／Ｌ比值）。对照组在给药后肝脏迅速清晰地显像，而心影较弱，其Ｈ／Ｌ比值为０．１４１±０．０４９。肝硬化门体分流组，肝影较弱而心影明显，其Ｈ／Ｌ比值明显高于对照组。Ｈ／Ｌ比值与肝功能Ｃｈｉｌｄ－Ｐｕｇｈ分级有明显的相关性。同时对５例肝硬化伴食管静脉曲张出血后患者服用心得安前后监测Ｈ／Ｌ比值，发现患者在服用心得安后Ｈ／Ｌ比值较服药前降低（Ｐ＜０．０５）。~（９９ｍ）Ｔｃ－ＭＩＢＩ经直肠给药门静脉显像可作为无创伤性监测肝硬化门体分流及药物治疗反应的方法。
Twenty-six patients with cirrhosis, 5 with non-cirrhosis and 10 with non-hepatobiliary disease (control group) received rectal administration of ~ (99m) TcMIBI to determine the ratio of H / L imaging (H / L ratio ). In the control group, the liver was rapidly and clearly visualized after administration, while the heart shadow was weaker. The H / L ratio was 0.141 ± 0.049. Liver cirrhosis portosystemic shunt group, liver shadow is weak and significant heart shadow, the H / L ratio was significantly higher than the control group. There was a significant correlation between H / L ratio and Child-Pugh classification of liver function. At the same time, H / L ratio was monitored in 5 patients with cirrhosis and esophageal variceal bleeding before and after administration of propranolol. The H / L ratio of patients after taking propranolol was significantly lower than that before medication (P <0.05). ~ (99m) Tc-MIBI rectal portal vein imaging can be used as a noninvasive method to monitor the shunt of liver cirrhosis and drug treatment response.