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研究慢性萎缩性胃炎（ＣＡＧ）、胃粘膜上皮不典型增生（ＡＴＰ）与胃癌的相关性。方法：所有３５０例中～重度ＣＡＧ患者均经内镜活检病理确诊，按队列研究，病例组１６０例系ＣＡＧ伴中～重度ＡＴＰ患者，对照组１９０例则为单纯ＣＡＧ患者，经１～９年（平均５．５年）的内镜和活检病理随访，观察两组癌变率。结果：共发生胃癌２９例，其中病例组癌变率１６．２％（２６／１６０），对照组１．６％（３／１９０）（ＲＲ＝１０．２９，Ｐ＜０．００１），与对照组比较，伴中度ＡＴＰ癌变率７．５％（７／９３）（ＲＲ＝４．７６，Ｐ＜０．０５），伴重度ＡＴＰ癌变率２８．４％（１９／６７）（ＲＲ＝１７．９６，Ｐ＜０．００１）。结论：ＣＡＧ、胃粘膜上皮ＡＴＰ均与胃癌相关，当两者合并存在时，较单纯ＣＡＧ癌变危险性增加１０倍之多，且ＣＡＧ伴ＡＴＰ程度越重，癌变危险性越大
To study the relationship between chronic atrophic gastritis (CAG) and gastric dysplasia (ATP) and gastric cancer. Methods: All 350 patients with moderate to severe CAG were diagnosed by endoscopic biopsy. According to a cohort study, 160 patients with CAG with moderate to severe ATP were included in the case group and 190 patients with simple CAG in the control group. After 1 to 9 years (Average 5.5 years) endoscopic and biopsy pathological follow-up, the incidence of cancer was observed in both groups. Results: A total of 29 cases of gastric cancer occurred, of which 16.2% (26/160) in the case group and 1.6% (3/190) in the control group (RR = 10.29, P <0.001) Compared with the control group, the rates of moderate canceration of cancer were 7.5% (7/93) (RR = 4.76, P <0.05) and 28.4% (19/67) .96, P <0.001). Conclusions: Both CAG and gastric mucosal epithelium ATP are associated with gastric cancer. When the two are combined, the risk of canceration is increased by 10 times compared with that of simple CAG. The more CAG with ATP, the greater the risk of carcinogenesis