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据美国国家科学院院刊报道,结合超声能量和超声微泡在细胞上打孔可能成为与心血管疾病和癌症作斗争的新工具。匹兹堡大学的研究人员称这种基因治疗方法为声孔效应疗法。现研究已经证明,一个微气泡振荡引起的切应力阈值大约1 kPa,当压力超过这个值,内皮细胞膜通透性增加。切应力阈值显示出与振荡周期数目和从0.5~2.0 Hz超声频率的一个逆平方根关系。此外,通过实时三维共焦显微镜的测量证
According to the Proceedings of the National Academy of Sciences, drilling holes in cells in combination with ultrasound energy and ultrasound microbubbles could be a new tool in the fight against cardiovascular disease and cancer. Researchers at the University of Pittsburgh say the gene therapy is sound-hole therapy. It has been shown that the shear stress threshold caused by a microbubble oscillation is about 1 kPa. When the pressure exceeds this value, the endothelial cell membrane permeability increases. The shear stress threshold shows an inverse square root of the number of oscillations and the ultrasonic frequency from 0.5 to 2.0 Hz. In addition, through the real-time three-dimensional confocal microscope measuring card