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本文回顾总结了临床试验研究他汀类药物在降脂治疗中的作用,如对缺血性心脏病患病率和死亡率的一级预防,对冠心病相关事件的二级预防等,证实他汀类药物可降低胆固醇,减少冠心病事件的危险性。详细介绍了如何合理应用他汀类药物,包括适应症、药物选择、联合用药、非药物治疗、辅助药物治疗等;提出用药物期间安全性检测指标和不良反应监测;最后对他汀类药物进行药效评价和展望。
This review summarizes the clinical trials of statins in the role of lipid-lowering therapy, such as the primary prevention of ischemic heart disease morbidity and mortality, secondary prevention of coronary heart disease-related events, confirmed that statins Drugs can lower cholesterol and reduce the risk of coronary heart disease. It introduces in detail how to use statins rationally, including indications, choice of drugs, combination therapy, non-drug therapy, adjuvant drug therapy, etc .; puts forward the safety test indicators and adverse reaction monitoring during the drug; Finally, the statin efficacy Evaluation and outlook.