目的:探讨新疆地区维吾尔族SLE的临床和免疫学特征。方法:收集并分析在新疆维吾尔自治区人民医院风湿免疫科住院且资料完整的211例维吾尔族SLE和同期的273例汉族SLE患者的临床资料。结果:①维吾尔族SLE患者211例，其中女性195例，男性16例，发病年龄15~64岁，平均（35±12）岁，病程0.1~228个月，平均（21±35）个月；②临床特征：维吾尔族SLE患者临床特征前5位分布为：肾脏受累56.4%（119/211），血液系统受累56.4%（119/211），皮疹50.2%（106/211），关节炎49.8%（105/211），乏力47.9%（101/211）；与汉族SLE患者相比较，维吾尔族SLE患者雷诺现象出现比例低（n χ2=6.066，n P=0.014）且差异有统计学意义；③免疫学特征：维吾尔族SLE患者自身抗体的分布分别是：ANA：94.8%（200/211），抗dsDNA抗体54.5%（115/211），抗SSA抗体47.9%（101/211），抗Un 1核糖核蛋白（Un 1-RNP）抗体35.1%（74/211），抗组蛋白（AHA）抗体28.4%（60/211）；与汉族SLE患者相比，维吾尔族SLE患者抗AHA抗体（n χ2=4.952，n P=0.026）的比率明显高于汉族SLE患者，更易出现贫血（n χ2=6.904，n P=0.009）、补体下降（n χ2=6.330，n P=0.012），且差异有统计学意义。n 结论:本研究未发现新疆地区维吾尔族SLE与汉族SLE患者在常见临床表现方面存在明显差异，维吾尔SLE族患者更易出现贫血、补体的下降，差异的产生可能与种族、饮食习惯等有关。“,”Objective:To describe the clinical features and immunological of Uygur systemic lupus erythematosus (SLE) subjects.Methods:Atotal of 484 adult patients (≥18 years) followed in the People's Hospital of the Xinjiang Uygur Autonomous Region were included into this study including 211 Uygur patients with SLE and 273 Han patients with SLE.Results:① Of the 211 Uygur SLE patients, 195 (92.4%) were female and 16(7.6%) were male (female:male=12.2∶1), the mean age at SLE onset was 15-64(35±12) years, mean disease duration was 0.1-228(21±35) months.② Of the 211 Uygur SLE patients, the most prevalent clinical presentationswere renal involvement 56.4%(119/211), hematological 56.4%(119/211), rash 50.2% (106/211), arthralgia/arthritis 49.8%(105/211), weakness 47.9%(101/211). The significant difference observed between the Uygur and Han SLE patients was Raynaud phenomenon( n χ2=6.066, n P=0.014) .③ The positive rates of antinuclear antibodies were 94.8%(200/211), 54.5%(115/211) for anti-dsDNA antibodies, 47.9% (101/211) for anti-SSA antibodies, 35.1%(74/211) for anti-Un 1-RNP antibodies, and 28.4%(60/211) for anti-AHA antibodies. The positivity of anti-AHA antibodies ( n χ2=4.952, n P=0.026) was higher in Uygur SLE patients than thatin Han SLE patients. More Uygur SLE patients were anemic ( n χ2=6.904, n P=0.009), with decrease of complement ( n χ2=6.330, n P=0.012).n Conclusion:This study can not find any significant differences between the Uygur SLE patients and Han SLE patients in common clinical manifestations in Xinjiang. The Uygur SLE patients are more likely to have anemia and decrease of complement, which may be related to race and diet habits.