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目的:研究黄芩提取物胶囊中黄芩苷在Beagle犬体内的药代动力学。方法:采用HPLC法测定Beagle犬血浆中的黄芩苷浓度。结果:黄芩苷在Beagle犬体内的动力学符合一室模型,t1/2在10h左右。结论:黄芩苷在Beagle犬体内的消除比较缓慢。
OBJECTIVE: To study the pharmacokinetics of baicalin in beagle dog extract capsules. Methods: Baicalin concentration in Beagle dog’s plasma was determined by HPLC. Results: The kinetics of baicalin in Beagle dogs was consistent with one-compartment model, with t1 / 2 around 10h. Conclusion: Baicalin is slowly eliminated in Beagle dogs.