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诺氟沙星是近10多年来新崛起的一种抗菌药物,其抗菌谱广,毒副作用低,无交叉耐药性,用于各种细菌感染的治疗,效果良好,应用广泛。我们自拟处方,制备了诺氟沙星栓剂,并试用紫外分光光度法直接测定了8例志愿受试者24h尿中诺氟沙星栓剂的排泄量,并求算药物动力学参数。1 仪器与药品1.1 UV-120-02型紫外分光光度计(日本岛津);UV-210-A型紫外分光光度计(日本岛津);PG-1500计算机(日本岛津)。1.2 诺氟沙星对照品(内蒙古包头制药厂提供,熔点218～222℃,含量99.9％);诺氟沙星栓剂(自拟处方制备,其重量差异和融变时限均符合《中国药典》1995年版有关规定)。
Norfloxacin is a newly emerging antimicrobial agent in recent 10 years. It has broad antimicrobial spectrum, low toxic and side effect, no cross-resistance and is used in the treatment of various bacterial infections with good effect and wide application. We prepared a prescription, prepared norfloxacin suppository, and UV spectrophotometry was used to test the urinary excretion of norfloxacin for 24 hours in 8 volunteers directly, and to calculate the pharmacokinetic parameters. 1 instruments and pharmaceuticals 1.1 UV-120-02 UV spectrophotometer (Shimadzu); UV-210-A UV spectrophotometer (Shimadzu); PG-1500 computer (Shimadzu). 1.2 Norfloxacin reference substance (provided by Inner Mongolia Baotou Pharmaceutical Factory, melting point 218 ~ 222 ℃, content 99.9%); norfloxacin suppository (self-prepared prescription, the weight difference and melting time are in line with the “Chinese Pharmacopoeia” 1995 Year version of the relevant provisions).