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目的研究临床处方中因西药联合使用不合理所导致的不良反应症状,分析这些处方的不合理之处,为西药临床的合理联合用药给出指导和建议。方法依照国家卫生部和药监局的相关用药规定和标准,从电脑系统记录中随机抽取我院于2013年6月~2015年5月期间开具的4 231张处方进行回顾性分析并统计分析结果。结果发现不合格处方294张,其中208份处方属于不合理联用,包括重复用药、配伍缺陷和毒副作用加强等,不合理联用的发生率高达4.9%。结论西药合用所出现的联用不合理现象还较普遍,造成这种严重情况的原因难以简单概括,必须深入了解常用药物的作用机理及药性特征,谨慎合理的联合用药才能尽可能减少患者的治疗风险,提高用药安全性。
Objective To study the symptoms of adverse reactions caused by unreasonable combination of western medicine in clinical prescriptions and to analyze the unreasonableness of these prescriptions and provide guidance and suggestions for rational combination therapy of western medicine. Methods According to the relevant prescriptions and standards of the State Ministry of Health and Food and Drug Administration, 4 231 prescriptions issued by our hospital from June 2013 to May 2015 were retrospectively analyzed and statistically analyzed. . As a result, 294 unqualified prescriptions were found, of which 208 were unreasonable, including repeated medication, incompatibility defects and side effects. The incidence of unreasonable combination was as high as 4.9%. Conclusions The unite unreasonable phenomenon appeared in the combination of western medicine is still more common. It is difficult to summarize the reasons of this serious situation. Therefore, it is necessary to understand the mechanism of action and the medicinal characteristics of commonly used medicines in a deep and reasonable way, and to minimize the treatment of patients Risk, improve drug safety.