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室颤时,闭胸心肺复苏(CPR)产生的冠脉血流不足以维持心肌的氧合作用。过去的研究结果表明,在CPR时,普荼洛尔可减少心肌需氧量和提高冠脉灌注压。本研究旨在检测,在CPR时β-肾上腺素能阻滞剂对除颤率和复苏后左室功能的影响。 方法 22只狗,平均体重20.7kg(范围17.3～24.5kg),被随机等分成两组。麻醉,插管,机械通气,开胸,植入体内除颤器,经血管插入尖端装有高精密度压力计的导管,供试验记录。给所有狗记录第一次基础测值。普荼洛尔组的11只狗注射普荼洛尔
During VF, coronary blood flow produced by closed-chest CPR is insufficient to maintain myocardial oxygenation. Past research has shown that propafol reduces myocardial oxygen demand and increases coronary perfusion pressure at CPR. The aim of this study was to determine the effect of β-adrenergic blockers on defibrillation and left ventricular function after resuscitation at CPR. Methods Twenty-two dogs, mean body weight 20.7 kg (range 17.3-24.5 kg), were randomly divided into two groups. Anesthesia, intubation, mechanical ventilation, thoracotomy, implantation of an internal defibrillator, catheterization of a catheter fitted with a high-precision pressure gauge at the tip of the blood vessel, for test recording. Record the first baseline measurement for all dogs. Eleven dogs in the popol group received poplar