In order to develop a novel kidney-targeted drug delivery system,a small molecular carrier (2-deoxy-2-aminodiglucose) was synthesized,and then the 2-deoxy-2-aminodiglucose-prednisolone conjugate (DPC) was synthesized to verify the kidney targeting capability of the carrier.Both 2-deoxy-2-aminodiglucose and DPC were confirmed by NMR and MS spectrum.The tissue distribution studies showed that DPC presented an excellent kidney targeting propertyin vivo,compared with prednisolone group,4.9-fold of drug concentration in kidney was observed in the DPC group.Thus,it indicated that 2-deoxy-2-aminodiglucose could be a potential carrier for kidney-targeted drug delivery.