论文部分内容阅读
本发明公开了一种合成2-[3-(S)-[3-[2-(7-氯-2-喹啉基)乙烯基]苯基]-3-羟基丙基]苯甲酸甲酯的工艺,由2-[3-(S)-[3-[2-(7-氯-2-喹啉基)乙烯基]苯基]-3-氧代丙基]苯甲酸甲酯和(-)β-二异松蒎基氯硼烷反应,并经后处理纯化得到2-[3-(S-[3-[2-(7-氯-2-喹啉基)乙烯基]苯基]-3-羟基丙基]苯甲酸甲酯。与传统工艺相比,本发明显著降低
Disclosed is a method for synthesizing methyl 2- [3- (S) - [3- [2- (7-chloro-2- quinolyl) ethenyl] phenyl] -3-hydroxypropyl] benzoate Was prepared from 2- [3- (S) - [3- [2- (7-chloro-2- quinolinyl) ethenyl] phenyl] -3- oxopropyl] benzoate and -) β-diisopinocaproyl chloride borane and purified by workup to give 2- [3- (S- [3- [2- (7-chloro-2- quinolinyl) ethenyl] phenyl ] -3-hydroxypropyl] benzoate The present invention is significantly reduced compared to the conventional process