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人免疫缺陷病毒(HIV)感染引起的结核病是一个日益严重的公共卫生问题。作者在海地的首都太子港进行了异烟肼与单服维生素B6的随机对照研究,以评定异烟肼对无症状HIV感染者预防活动性结核病的作用,并对预防HIV疾病、艾滋病及死亡发生的作用也进行了评价。受试者为18～65岁新近确诊的无症状HIV感染者,将其随机分为两组:治疗组每日服异烟肼300rag加维生素B650mg,共12个月;对照组单服维生素B650mg 12个
Tuberculosis caused by human immunodeficiency virus (HIV) infection is a growing public health problem. The authors conducted a randomized controlled study of isoniazid versus single vitamin B6 in Port-au-Prince, Haiti to assess the role of isoniazid in preventing active tuberculosis in asymptomatic HIV-infected individuals and to prevent HIV disease, AIDS and death The role was also evaluated. The subjects were 18-24-year-old newly diagnosed asymptomatic HIV-infected persons were randomly divided into two groups: the treatment group daily isoniazid 300rag plus vitamin B650mg for 12 months; the control group single-vitamin B650mg 12 A