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目的评价快速试纸法检测尿胰蛋白酶原-2对小儿急性胰腺炎(AP)的诊断价值。方法收集以急性腹痛和(或)呕吐为主诉入院的33例患儿的血液及尿液标本,分别检测其尿胰蛋白酶原-2、血淀粉酶、尿淀粉酶及血脂肪酶。参考2004年中国急性胰腺炎诊治指南(草案)推荐的诊断标准,将患儿分为AP组(17例)和非AP组(16例)。比较二组上述4项检测指标的阳性率及敏感性、特异性、阳性预测值、阴性预测值及准确度。应用SPSS13.0软件进行统计学分析。结果 AP组尿胰蛋白酶原-2、血淀粉酶、尿淀粉酶及血脂肪酶的阳性率明显高于非AP组,差异均有统计学意义(Pa<0.01)。尿胰蛋白酶原-2诊断AP的敏感性、特异性、阳性预测值、阴性预测值及准确度分别为88.24%、100.00%、100.00%、88.89%和93.94%。结论快速试纸法检测尿胰蛋白酶原-2具有早期、简便、准确、快速等优点,较血淀粉酶、尿淀粉酶和血脂肪酶更具有诊断优势,是诊断小儿AP的一个非常有价值的诊断方法。
Objective To evaluate the diagnostic value of urinary trypsin-2 in children with acute pancreatitis (AP) by rapid test strip method. Methods Thirty-three children admitted to hospital with acute abdominal pain and / or vomiting were collected for blood and urine samples. Urinary trypsinogen-2, blood amylase, urinary amylase and lipase were detected respectively. According to the diagnostic criteria recommended by the Chinese Guideline for Diagnosis and Treatment of Acute Pancreatitis in 2004, the children were divided into AP group (17 cases) and non-AP group (16 cases). The positive rate, sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the above four test indexes were compared between the two groups. Application SPSS13.0 software for statistical analysis. Results The positive rates of urinary trypsinogen-2, blood amylase, urinary amylase and lipase in AP group were significantly higher than those in non-AP group (P <0.01). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of urinary trypsinogen-2 in the diagnosis of AP were 88.24%, 100.00%, 100.00%, 88.89% and 93.94%, respectively. Conclusion The rapid test strip method for the detection of urinary trypsinogen-2 has many advantages, such as early, simple, accurate and rapid. It has more diagnostic advantages than blood amylase, urine amylase and lipase, and it is a very valuable diagnosis for diagnosing pediatric AP method.