论文部分内容阅读
核因子(NF)-κB是一种广泛存在的核转录因子,它参与多种基因的转录调控,与细胞凋亡等生理病理过程关系密切。抑制因子κB(IκK)作为NF-κB的抑制子,在NF-κB活化的途径中起着最关键的分子开关作用,IκB家族包括IκBa、IκBβ、IκBε、IκBγ(p105)Bcl-3和IκBδ(p100)。各种刺激下神经元和胶质细胞中NF-κB的活化及靶基因转录不同,对细胞凋亡影响不同;神经元和胶质细胞IκBs代谢动力学也存在差异,选择性地针对IκBs亚型或其上游IκB激酶可能达到调控神经细胞凋亡的目的。
Nuclear factor (NF) -κB is a ubiquitous nuclear transcription factor that is involved in the transcriptional regulation of a variety of genes and is closely related to the physiological and pathological processes such as apoptosis. Inhibitors of NF-κB (IκK), as inhibitors of NF-κB, play the most crucial molecular switch in the pathway of NF-κB activation. The IκB family includes IκBa, IκBβ, IκBε, IκBγ (p105) Bcl-3 and IκBδ p100). The activation of NF-κB and the transcription of target genes in neurons and glial cells under various stimuli have different effects on apoptosis. The IκBs metabolic kinetics of neurons and glial cells are also different, selectively targeting IκBs subtype Or its upstream IκB kinase may achieve the purpose of regulating neuronal apoptosis.