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红花是一种古老的中草药,从汉代张仲景著的《金匮要略》就有记载。它主要有活血通经,祛瘀止痛的功效。随着现代分离和提纯工艺的发展,已从中药红花花瓣中提取出它的活性成分,红花黄色素(safflower yellow,SY),它是一种水溶性的查耳酮类化合物。研究已证明[1-5],红花黄色素具有抗血栓、抗氧化、降脂、抗炎、抗细胞凋亡、抗纤维化等多种药理作用,已应用于缺血性心脑及外周血管疾病的治疗。近年来有多项研究报道,将红花黄色素用于肾脏病的治疗,取得很好的疗效。现将其进行综述,为今后其在肾脏疾病中更广
Safflower is an ancient Chinese herbal medicine, from the Han Dynasty Zhang Zhongjing’s “Golden Chamber” is recorded. It mainly has the effect of promoting blood circulation and removing blood stasis and relieving pain. With the development of modern separation and purification processes, safflower yellow (SY), a water-soluble chalcone compound, has been extracted from the Chinese safflower petal. Studies have demonstrated [1-5], safflower yellow with anti-thrombotic, anti-oxidation, lipid-lowering, anti-inflammatory, anti-apoptosis, anti-fibrosis and other pharmacological effects, has been used in ischemic heart and brain Treatment of vascular disease. In recent years, a number of studies have reported that safflower yellow pigment for the treatment of kidney disease, and achieved good results. It is now reviewed for the future of its broader kidney disease