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研究了盐酸维拉帕米 (VH)与强酸性阳离子交换树脂 (0 0 1× 7)的交换反应动力学及其药物树脂复合物在去离子水、0 5mol/L、1 0mol/L、2 0mol/LNaCl和 0 5mol/LHCl以及 0 5mol/LKCl溶液中的释药动力学 .交换动力学结果表明 ,随温度的升高 ,药物与树脂的交换率增加 ,交换反应达平衡时 ,VH的平衡常数为 0 0 5 2 7;VH与 0 0 1× 7树脂的交换过程属于粒扩散过程控制 .体外释药动力学研究表明 ,VH药物树脂复合物在去离子水中不释放药物 ,但其释药速率随介质中离子强度的增加而增加 ;其释放动力学过程可用Viswanathan方程来描述 ,并且VH在上述释放介质中的释放属于粒扩散过程控制 ,粒扩散系数随释放介质中离子强度的增加而增加 .
The exchange reaction kinetics of verapamil hydrochloride (VH) with strongly acidic cation exchange resin (0 0 1 × 7) and its drug-resin complex in deionized water, 0 5mol / L, 10mol / L, 2 0mol / L NaCl and 0 5mol / LHCl and 0 5mol / L KCl solution.The exchange kinetics results show that with the increase of temperature, the exchange rate of drug and resin increases, the exchange reaction reaches equilibrium, the balance of VH The constant is 0 0 5 2 7, and the exchange process between VH and 0 0 1 × 7 resin is controlled by the process of particle diffusion.The in vitro drug release kinetics studies show that VH drug-resin complexes do not release drugs in deionized water, The rate of increase with the increase of ionic strength in the medium; the release kinetics can be described by the Viswanathan equation, and the release of VH in the above release medium is controlled by the process of particle diffusion. The particle diffusion coefficient increases with the increase of ionic strength in the release medium .