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复方地塞米松滴鼻液是新一代治疗过敏性鼻炎用药 ,其主要成分为地塞米松磷酸钠和盐酸麻黄碱。该药在临床上治疗反复发作的过敏性鼻炎取得良好的效果[1,2 ] 。为了便于直接考察制剂的质量和稳定性 ,我们建立了用苯甲酸做内标的反相高效液相色谱法测定滴鼻液中地塞米松磷酸钠的含
Compound dexamethasone nasal drops is a new generation of drugs for the treatment of allergic rhinitis, the main components of dexamethasone sodium phosphate and ephedrine hydrochloride. The drug in the clinical treatment of recurrent allergic rhinitis achieved good results [1,2]. In order to facilitate the direct examination of the quality and stability of the formulation, we established a method for the determination of dexamethasone sodium phosphate in nasal drops by RP-HPLC with benzoic acid as internal standard