目的观察流感疫苗对老年慢性阻塞性肺疾病(COPD)患者病情干预效果。方法选取112例老年COPD稳定期患者,对照组54例给予常规解痉、平喘、化痰治疗,接种组58例在此基础上给予流感疫苗接种,观察两组患者1年内的病情发展情况及疫苗接种组的不良反应。结果接种组患者1年内急性发作次数(2.91±1.70)、急性期病程(38.78±17.63)d及因急性发作住院次数(1.03±0.61)次、住院天数(12.36±6.32)d,明显低于对照组[分别为(5.22±2.14)、(49.63±21.25)d、(1.98±0.84)次、(17.73±7.85)d],差异有统计学意义(P<0.01);肺功能指标及6分钟步行距离测试两组差异无统计学意义(P>0.05);接种组局部反应发生率5.17%,未见全身不良反应。结论老年COPD患者接种流感疫苗后不良反应率低且轻微,可降低急性发作次数及住院次数,但对肺功能、运动耐力的改善、病死率等尚需追踪观察。 Objective To observe the effect of influenza vaccine on elderly patients with chronic obstructive pulmonary disease (COPD). Methods A total of 112 elderly patients with stable COPD were enrolled in the study. 54 patients in the control group were treated with conventional antispasmodic, antiasthmatic and phlegm-resolving methods. Inoculated group, 58 patients were given influenza vaccination. Adverse reactions to the vaccination group. Results The numbers of acute attacks (2.91 ± 1.70), acute phase (38.78 ± 17.63) d, acute hospitalizations (1.03 ± 0.61) and length of hospital stay (12.36 ± 6.32) days in inoculation group were significantly lower than those in control (P <0.01). The indexes of pulmonary function and 6-minute walk were significantly higher than those of the control group (5.22 ± 2.14, 49.63 ± 21.25 d, 1.98 ± 0.84, and 17.73 ± 7.85 d, respectively) There was no significant difference between the two groups in distance test (P> 0.05). The incidence of local reaction in vaccinated group was 5.17%. No systemic adverse reactions were observed. Conclusions The incidence of adverse reactions and the number of hospitalizations in elderly patients with COPD after influenza vaccination are low and slight, but the improvement of pulmonary function, exercise endurance and mortality are still to be followed up.