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目的 探讨急性、慢性肝炎血清总胆汁酸（ＴＢＡ）测定的可能作用。方法 经肝穿刺活检病理证实为急性、慢性病毒性肝炎９２ 例，对ＴＢＡ含量进行了测定，并与ＡＬＴ及Ｔｂｉｌ进行对比分析。结果 急性肝炎与慢性肝炎ＴＢＡ与正常组比较有显著性差异（Ｐ均＜ ０．００１），慢性肝炎轻、中、重型三组ＴＢＡ经χ２ 和ｔ检验，各组比较无显著性差异（Ｐ＞ ０．０５）。结论 急性肝炎时ＴＢＡ检测与ＡＬＴ同样具有高度灵敏性，在慢性肝炎ＴＢＡ敏感性明显高于ＡＬＴ及Ｔｂｉｌ的检测，但并不能准确反映肝脏病变轻重。
Objective To investigate the possible role of serum total bile acid (TBA) in acute and chronic hepatitis. Methods Totally 92 cases of acute and chronic viral hepatitis were confirmed by biopsy of liver biopsy. The content of TBA was measured and compared with ALT and Tbil. Results TBA in acute hepatitis and chronic hepatitis were significantly different from those in normal group (all P <0.001). There was no significant difference in TBA among mild, moderate and severe chronic hepatitis among the three groups (P> 0.05). Conclusions TBA in acute hepatitis is highly sensitive to ALT. The sensitivity to TBA in chronic hepatitis is obviously higher than that in ALT and Tbil, but it can not accurately reflect the severity of liver disease.