病毒性心肌炎(VMC)是一种由各种病毒引起的自身免疫性疾病,其中以柯莎奇B组病毒(CVB)导致的VMC最为常见。VMC容易导致心力衰竭、心律失常等并发症,也是心源性猝死的原因之一。VMC心肌组织中存在明显的细胞凋亡和缝隙连接蛋白变化,细胞凋亡和缝隙连接蛋白可能参与了VMC的发生和发展,在其发病机制中起重要作用。 Viral myocarditis (VMC) is an autoimmune disease caused by a variety of viruses, of which VMC caused by Coxsackie B virus (CVB) is the most common. VMC easily lead to heart failure, arrhythmia and other complications, but also one of the causes of sudden cardiac death. There were obvious changes of apoptosis and connexin in myocardium of VMC. Apoptosis and connexin might be involved in the occurrence and development of VMC, which play an important role in the pathogenesis of VMC.