压汞法在粉末冶金、催化剂等研究中已广泛应用,1956年国外开始将此项技术应用于药学领域。片剂和颗粒剂都是多孔性固体,孔结构直接与其理化性质有密切关系,从而影响药物的崩解、溶解、吸收及稳定性。 本工作选用直接压片的新型赋形剂Tri-Tab,在不同压力下制片, 用孔度仪测定孔大小分布与片子性质的关系,并从滞后现象分析样品的孔结构。 Mercury intrusion in powder metallurgy, catalysts and other research has been widely used in 1956 abroad began to apply this technology in the field of pharmacy. Tablets and granules are porous solids, the pore structure is directly related to its physical and chemical properties, thus affecting the drug disintegration, dissolution, absorption and stability. In this work, a new type of direct tabletting excipient, Tri-Tab, was used to make tablets under different pressures. The relationship between pore size distribution and film properties was determined with a porosimeter, and the pore structure of the samples was analyzed from the hysteresis.