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丁型肝炎病毒(Delta agent 或δ—因子)的发现使我们对慢性HBV感染以及发展成为严重的肝损害等有了进一步的认识。HDV是一种可传染的、有缺陷的、嗜肝的独特RNA病毒。它的出现和复制主要依靠HBV的复制。HDV外层有HBsAg,核心有δ-因子。因此,δ-病毒感染只能发生在具有HBV感染的患者,既可与急性HBV感染同时存在(并存感染),也可在慢性感染后再感染(重复感染)。血清中高滴度δ-抗体或肝标本内出现δ-抗原,即可作出慢性δ-感染诊断。慢性乙肝重复感染δ-病毒时常可并发急性肝炎,同时可使肝组织恶
The discovery of the hepatitis D virus (delta agent or delta-factor) has given us a better understanding of chronic HBV infection and the development of severe liver damage. HDV is a contagious, defective, hepadnavirus unique RNA virus. Its appearance and replication rely mainly on HBV replication. HDV outer HBsAg, the core of δ-factor. Therefore, delta-virus infection can only occur in patients with HBV infection, both with acute HBV infection (coexisting infection), but also after infection with chronic infection (repeated infection). Serum high titer of δ-antibody or δ-antigen appears in the liver specimens, you can make a diagnosis of chronic δ-infection. Chronic hepatitis B repeated infection Delta-virus often complicated by acute hepatitis, liver necrosis at the same time