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β-肾上腺素能受体兴奋剂(β-兴奋剂)是常用的一类平喘药,其中异丙肾上腺素问世最早,它对β_1和β_2受体均有兴奋作用。近十多年来应用比较广泛的有舒喘宁、间羟异丙肾上腺素、酚丙喘宁(fenoterol)、叔丁喘宁(terbutaline)、氯喘、氨双氯喘通、哌喘定(rimiterol)及KWD_(2131)等。它们都相对选择性地作用于β_2受体,因此有明显的舒张支气管的作用而较少引起心血管的副反应。药理作用舒张支气管哮喘病人气道阻塞的程度和性质可依据各种肺功能指标来判断,临床上常选择1秒钟用力呼气量(forced expiratory volume in one second,FEV_1)和呼气流量峰值(peak expiratory flow rate,PEFR),因为这两种方法都比较敏
β-adrenergic receptor agonist (β-agonist) is a commonly used class of antiasthmatic drugs, of which isoproterenol came out earliest, it β3 and β2 receptors are excited. Over the past 10 years, the most widely used are salbutamol, metaproterenol, fenoterol, terbutaline, chlorine, ammonia dichloride, rimiterol) and KWD_ (2131) and so on. They all act relatively selectively on the beta 2 receptor and therefore have a pronounced diastolic bronchial effect with less cardiovascular side effects. Pharmacological effects Diastolic bronchial asthma patients with airway obstruction and the nature of the nature of the lung function can be based on a variety of indicators to judge the clinical choice of forced expiratory volume in one second (forced expiratory volume in one second (FEV_1) and peak expiratory flow ( peak expiratory flow rate, PEFR), because both methods are more sensitive