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目的:探讨白术多糖对单纯高脂饮食诱导的大鼠非酒精性脂肪性肝炎的防治作用。方法:采用高脂饮食14周诱导的大鼠非酒精性脂肪性肝炎模型。在造模第9周起,随机分为模型组、白术多糖组和罗格列酮对照组,灌胃给药6周。观察:(1)肝组织病理变化(HE染色);(2)肝组织甘油三酯(TG)、游离脂肪酸(FFA)含量的变化;(3)血清谷丙转氨酶(ALT)、谷草转氨酶(AST)活性的变化。结果:模型组肝组织出现显著的肝细胞脂肪变性及空泡样变,肝组织TG、FFA含量较正常组显著升高(P<0.01),血清ALT、AST活性较正常组亦明显升高(P<0.01)。白术多糖的上述病理改变显著减轻,肝组织TG、FFA含量及血清ALT、AST水平显著低于模型组(P<0.01)。结论:白术多糖具有良好的防治非酒精性脂肪性肝炎的药效学效应。
Objective: To investigate the prevention and treatment of Atractylodes macrocephala polysaccharide on nonalcoholic steatohepatitis induced by simple high fat diet in rats. Methods: A rat model of nonalcoholic steatohepatitis induced by high fat diet for 14 weeks was used. From the 9th week of model establishment, the rats were randomly divided into model group, Atractylodes macrocephala group and rosiglitazone control group, which were given intragastrically for 6 weeks. (2) Liver triglyceride (TG), free fatty acid (FFA) content changes; (3) serum alanine aminotransferase (ALT), aspartate aminotransferase ) Activity changes. Results: The hepatic steatosis and vacuolar degeneration were observed in the model group. The content of TG and FFA in the liver tissue of the model group was significantly higher than that of the normal group (P <0.01) and the activity of ALT and AST in the model group was significantly higher than that of the normal group P <0.01). The above pathological changes of Atractylodes macrocephala were significantly alleviated. The levels of TG and FFA in liver tissue and serum ALT and AST were significantly lower than those in model group (P <0.01). Conclusion: Atractylodes polysaccharide has a good pharmacodynamic effect in preventing and treating nonalcoholic steatohepatitis.