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水杨酸盐类(主要指阿司匹林)是应用广泛的解热镇痛和抗风湿性药物。它的一般药理作用,包括对胃肠道的刺激等大家都知道。但它可致胃肠道大出血,则仅在1938年由Douthwait等提出,才引起了注意。根据近20多年来大量的实验和临床观察才得到公认,报告很多。鉴于本类药物应用十分普遍,且出血反应较其他副反应严重,值得重视。作者根据所读到的文献综述如下。有关临床发生频率资料1956年Kelly曾报告3例服阿司匹林所致之上消化道出血,并搜集文献复习讨论。1957年Bayo报告4例引致溃疡增剧、出血及肠出血老。根据统计分析,
Salicylates (mainly aspirin) are widely used antipyretic and antirheumatic drugs. It’s general pharmacological effects, including gastrointestinal stimulation, we all know. But it can cause gastrointestinal bleeding, it was only in 1938 by Douthwait, etc., before drawing attention. According to nearly 20 years a large number of experimental and clinical observation was recognized, a lot of reports. In view of the widespread use of this class of drugs, and bleeding reactions serious than the other side effects, it is worth attention. The author based on the literature read is summarized as follows. The frequency of clinical frequency Kelly had reported in 1956, 3 cases of upper gastrointestinal bleeding caused by aspirin and collect literature review discussion. Bayra reported in 1957, 4 cases led to increased ulcers, bleeding and intestinal bleeding. According to statistical analysis,