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目的:制备夏天无总碱多囊脂质体,并进行体外特征评价。方法:以包封率为评价指标,以卵磷脂(PC)与药物、PC与三油酸甘油酯(TO)、PC与磷脂酰丝氨酸(PS)、PC与胆固醇(CH)的质量比为考察因素,用复乳法制备夏天无总碱多囊脂质体;并考察其形态、粒径和体外释放行为。结果:PC与药物、PC与TO、PC与PS、PC与CH的质量比分别为10∶2、3∶1、4∶3、1∶2.5,包封率可达(50±3)%;多囊脂质体呈球状体,平均粒径为22.0μm,在生理盐水中体外释放时间可持续2d。结论:该制备工艺稳定、可行。
OBJECTIVE: To prepare non-total alkaloid multivesicular liposomes in summer and to evaluate the in vitro characteristics. Methods: The entrapment efficiency was used as the evaluation index, and the mass ratio of lecithin (PC) to drug, PC and glycerol trioleate (TO), PC and phosphatidylserine (PS), PC and cholesterol Factors, using double emulsion method to prepare non-total alkaloids multivesicular liposomes; and investigate its morphology, particle size and in vitro release behavior. Results: The mass ratio of PC to drug, PC, TO, PC and PS, PC and CH were 10: 2, 3:1, 4:1 and 1: 2.5, respectively. The multivesicular liposomes were spheroids with an average particle size of 22.0μm and the in vitro release time in physiological saline could last for 2 days. Conclusion: The preparation process is stable and feasible.