利用造影剂对肝脏肿瘤作早期诊断,是一项重要研究课题。1965年,作者曾按照肝脏内皮网状组织吞噬外源性颗粒的特性,设计合成了一系列新造影剂,经动物试验其中有一种含碘芳香化合物(TABAC)显影效果良好,毒性较低。初步临床病试用结果表明,对肝脏显影灵敏度较同位素扫描诊断为高。为了进一步了解本品在体内分布的情况,进行了药物代谢动力学研究。 The use of contrast media for early diagnosis of liver tumors is an important research topic. In 1965, the authors designed and synthesized a series of new contrast agents according to the characteristics of liver endodermis phagocytosis of exogenous particles. One of the iodinated aromatic compounds (TABAC) in animal experiments showed good developing effect and low toxicity. Preliminary clinical trial results show that the sensitivity of the development of the liver is higher than the isotope scan diagnosis. In order to further understand the distribution of this product in the body, conducted a pharmacokinetic study.