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20例原发性垂体性侏儒症、2例单纯性GH缺乏IA型及1例宫内生长停滞的患儿用经典性药物进行激发试验并于夜睡眠中采血测GH,确认有GH缺乏。全部病例用重组hGH治疗。20例用191肽的Genotropin,3例用192肽的Somatonorm,疗程12个月(后一组中1例治疗6个月)。结果一年后身高增长Genotropin组为13.3±1.8cm,Somatonorm组2例各为16.0、16.6cm,1例治疗6个月后为7.9cm。疗程中出现血清T_4下降、轻度肝肿大、一过性血尿者各占47.8％、30.4％、30.4％。
20 cases of primary pituitary dwarfism, 2 cases of simple GH deficiency type IA and 1 case of intrauterine growth arrest in patients with classical drug challenge test and take blood in the night sleep GH, GH deficiency was confirmed. All cases were treated with recombinant hGH. 20 cases of genotropin with 191 peptide and 3 cases of Somatonorm with 192 peptide were treated for 12 months (1 in the latter group was treated for 6 months). Results One year later the height growth was 13.3 ± 1.8 cm in Genotropin group, 16.0 cm in Somatonorm group and 16.6 cm in Somatonorm group, and 7.9 cm in one case after 6 months of treatment. Serum T_4 decreased, mild hepatomegaly, transient hematuria accounted for 47.8%, 30.4%, 30.4% respectively.