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目的:探讨妇女在无保护性生活超过120h,或多次无保护性生活后在黄体期使用米非司酮配伍米索前列醇避孕对月经的影响。方法:观察对象在黄体期一次性服用米非司酮100mg并在36～48h后服用米索前列醇400μg,服药后随访2个月经周期。结果:在成功避孕的289例(98.6%)中,服药前月经周期29.36±2.14d,服药当月月经周期26.15±3.68d,差异有统计学意义(t=15.498,P<0.05);服药前经期5.42±1.02d,服药后当月经期5.61±1.09d,差异有统计学意义(t=-4.143,P(0.05);服药后当月经量与自身既往经量比较,无变化215例(74.4%),减少59例(20.4%),增多15例(5.2%)。服药后次月月经周期为29.65±2.82d,与服药前相比差异无统计学意义(t=-1.922,P>0.05);经期5.46±1.03d,与服药前比较差异无统计学意义(t=-1.609,P>0.05);经量无变化273例(94.5%),减少10例(3.5%),增多6例(2.1%)。服药距预计月经时间越长月经提前的时间就越长(F=3.445,P<0.05)。结论:妇女黄体期使用米非司酮配伍米索前列醇避孕有效率高,可使服药当月月经周期缩短、经期延长,且服药距预计月经时间越长对月经影响越大,但对以后月经无影响。
OBJECTIVE: To investigate the effects of mifepristone and misoprostol on the menstrual cycle in women who have been exposed to unprotected sex for more than 120 hours, or after several unprotected lives. METHODS: Subjects were given 100 mg mifepristone once during the luteal phase and 400 μg misoprostol 36 to 48 h after the drug administration. The patients were followed up for 2 menstrual cycles. Results: Among the 289 cases (98.6%) of successful contraception, the menstrual cycle before treatment was 29.36 ± 2.14d and the menstrual cycle was 26.15 ± 3.68d during the medication period (t = 15.498, P <0.05) 5.42 ± 1.02d and 5.61 ± 1.09d after menstruation. The difference was statistically significant (t = -4.143, P (0.05)). There was no change in 215 cases (74.4% , Decreased by 59 cases (20.4%) and increased by 15 cases (5.2%). The menstrual cycle of the next month after medication was 29.65 ± 2.82 days, with no significant difference compared with that before medication (t = -1.922, P> 0.05) Mild period was 5.46 ± 1.03d, there was no significant difference compared with before treatment (t = -1.609, P> 0.05); there were 273 cases (94.5% %) .Dose taken from the expected menstrual period longer menstruation ahead of time longer (F = 3.445, P <0.05) .Conclusion: women luteal phase with mifepristone with misoprostol contraceptive effective, can make medication Menstrual cycle of the month shortened, menstrual prolongation, and medication away from the expected duration of menstruation, the longer the greater impact, but no effect on subsequent menstruation.