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目的:研究健乳灵对乳腺增生大鼠的治疗作用及对乳腺组织p16、p53表达的影响。方法: 75只大鼠随机分为5组,分别为正常对照组,模型组,高、中、低三个药物试验组。分别用不同剂量的健乳灵治疗60d,取乳腺组织观察乳腺的病理变化和p16、p53蛋白表达。结果:健乳灵三个剂量组均能抑制乳腺上皮增生,减少小叶和腺泡数目,降低大鼠乳腺增生组织的p16、p53蛋白表达水平, 与模型组比较有显著性差异(P<0. 01)。结论:健乳灵对大鼠乳腺增生病有调节和治疗作用。
Objective: To study the therapeutic effect of Jianruling on hyperplasia of mammary gland in rats and its effect on the expression of p16 and p53 in breast tissue. Methods: Seventy-five rats were randomly divided into 5 groups: normal control group, model group, high, middle and low drug test groups. After being treated with different doses of Jianlingling for 60 days, the mammary gland tissue was taken to observe the pathological changes of mammary glands and the expression of p16 and p53 proteins. RESULTS: Three doses of Jianlingling all inhibited the proliferation of mammary epithelium, reduced the number of lobular and acini, and decreased the expression of p16 and p53 protein in rat mammary gland hyperplasia. There was a significant difference from the model group (P<0. 01). Conclusion: Jianruling can regulate and treat hyperplasia of mammary gland in rats.