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住院的粒细胞缺乏症患者最常见的并发症为发热和感染。发热的发生率超过90%。在急性白血病方面,已对本症预防性地使用抗菌素进行了广泛的研究,其中有4大组对照工作做得比较好,此4大组的2组认为,预防性地使用不吸收口服抗菌素能有效地减少感染发生率;另2大组则未能获得同样的结果。同时一些口服不吸收抗菌素付作用多,不易为病者所接受。作者对111例次(分2组)粒细胞缺乏症患者预防性地应用TMP/SMZ(三甲氧基苄氨嘧啶/磺胺甲基异恶唑)以观察它对减少发热和感染,减少使用静脉注射大剂量抗菌素的作用。将住院的粒细胞缺乏症患者随机分为两组。治疗组:预防性口服TMP/SMZ,每日口服TMP 320
The most common complication of hospitalized agranulocytosis is fever and infection. The incidence of fever over 90%. In the field of acute leukemia, extensive studies have been conducted on the prophylactic use of antibiotics in the present disease, of which four groups are well controlled and the two groups of four groups consider that prophylactic use of non-absorption of oral antibiotics is effective Reduce the incidence of infection; the other two groups failed to get the same result. At the same time some oral antibiotics do not absorb the role of pay more difficult for patients to accept. The authors prophylactically applied TMP / SMZ (trimethoprim / sulfamethoxazole) to 111 patients with subgroups of patients with agranulocytosis to observe its effect on reducing fever and infection and reducing the use of intravenous The role of high-dose antibiotics. Inpatients with agranulocytosis were randomly divided into two groups. Treatment group: prophylactic oral TMP / SMZ, daily oral TMP 320