本文提出了复杂结构系统疲劳可靠性分析的一阶和二阶混合方法。引进Ｈｏｈｅｎｂｉｃｈｌｅｒ等提出的并联系统可靠性分析的二阶渐近式计算失效途径的疲劳失效概率；利用并联系统等效线性安全余量的概念，形成由失效途径的等效失效单元组成的串联系统；并最终计算整个系统的疲劳失效概率。计算结果表明，这一方法能有效地提高结构系统疲劳失效概率的计算精度。 In this paper, the first-order and second-order hybrid methods for fatigue reliability analysis of complex structures are proposed. The second order asymptotic failure probability of failure of parallel system proposed by Hohenbichler et al was introduced. By using the concept of equivalent linear safety margin of parallel system, a series system consisting of equivalent failure cells of failure route was formed. And finally calculate the probability of fatigue failure of the entire system. The calculation results show that this method can effectively improve the calculation accuracy of fatigue failure probability of structural system.