干细胞和肿瘤细胞都具有无限自我更新能力,二者的调节机制也有相似之处,如端粒酶的活化、凋亡的抑制等。越来越多的证据表明,一些癌瘤内有部分细胞具有类似干细胞的功能(肿瘤干细胞),其从急性髓细胞白血病、实体瘤(乳腺癌)、恶性神经胶质瘤中被分离出来,在放疗或化疗后可继续存活,对治疗有对抗作用,是维持癌瘤恶性的关键。文章介绍有关肿瘤干细胞的研究进展。 Both stem cells and tumor cells have an infinite self-renewal capacity, and the regulatory mechanisms of the two are similar, such as activation of telomerase and inhibition of apoptosis. There is growing evidence that some cells in some cancers have stem cell-like functions (tumor stem cells) that are isolated from acute myeloid leukemia, solid tumors (breast cancer), and malignant gliomas Radiotherapy or chemotherapy can continue to survive after the treatment has antagonistic effect, is to maintain the malignant tumor key. The article introduces the research progress of tumor stem cells.