Oksala(1954)报告在牛眼组织(角膜、玻璃体、视网膜、巩膜和晶体)中含微量元素铅浓度较高(200～800μg/kg湿重)。铅是一种重要的环境污染物,它对多种组织如肾脏、中枢神经和造血系统等有明显的毒性作用。以往报道铅能穿透血-脑屏障,而在眼中蓄积。业已证明在离体条件下,铅(200μg/L)能使视网膜光感受器发生改变。著者发现铅能影响晶体离子代谢,从而可引起白内障。作者用实验剂量的铅喂养兔,不能在眼液或晶体中检出铅。在兔的背部皮下植入一渗透泵,并以每日10mg/kg剂量连续释放铅,28天后,将动物杀死。所有标本在-60℃Becton Dickinson Oksala (1954) reported a high concentration of lead (200 to 800 μg / kg wet weight) in bovine ocular tissues (cornea, vitreous body, retina, sclera and crystals). Lead is an important environmental pollutant, which has obvious toxic effects on various tissues such as kidney, central nervous system and hematopoietic system. It has been reported in the past that lead can penetrate the blood-brain barrier and accumulate in eyes. Lead (200 μg / L) has been shown to alter retinal photoreceptors in vitro. The authors found that lead can affect the crystal ion metabolism, which can cause cataracts. The authors fed rabbits with experimental doses of lead and could not detect lead in eye drops or crystals. An osmotic pump was implanted subcutaneously in the back of the rabbit and lead was released serially at a daily dose of 10 mg / kg. After 28 days, the animals were sacrificed. All specimens were at -60 ° C Becton Dickinson