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引言 姐妹染色单体互换(sister chromat-id exchange,SCE)最早是由Taylor(1957)在植物细胞中发现的. 尽管细胞遗传学家们对SCE方法进行了各种尝试和改革,但始终没有脱离Zakh-arov和Egolina(1972)首先发现的用Br-dU掺入两个DNA复制周期来标记染色体.之后.Kato将这种无需氘标记的新方法称为BrdU标记法。由于它的出现,大大提高了SCE检出频率的可靠性和重复性。从此,SCE的研究在细胞遗传学领域中得到迅
INTRODUCTION Sister chromat-id exchange (SCE) was originally found in plant cells by Taylor (1957) .Although cytogenetics scientists have made various attempts and reforms to the SCE method, they have never had Chromosomes were removed from the DNA replication cycle with Br-dU, first discovered by Zakh-arov and Egolina (1972), and Kato later referred to this new method of deuterium labeling as the BrdU labeling method. Because of its appearance, the reliability and repeatability of SCE detection frequency are greatly improved. Since then, SCE research has been rapidly gaining prominence in the field of cytogenetics