“君”“臣”“佐”“使”的配伍,是中医方剂的组成原则。千百年来的实践证明,这种组方法度,具有很高的科学性。那么,在方剂配伍中各药所处的地位如何?药物之间内在联系的实质又是什么?笔者试从现代药理研究角度,对上述问题加以初步探讨。一君药是治疗主病或主症,起主要治疗作用的药物。因是针对主要矛盾而设,起着决定性的治疗作用,故在全方中占有主导地位。君药的性能规定和影响着整个方剂的性 The compatibility of “jun”, “confidence”, “adjurement” and “make” is the principle of composition of traditional Chinese medicine prescriptions. Thousands of years of practice have proved that this method is highly scientific. Then, what is the position of each drug in prescription compatibility? What is the essence of the internal link between drugs? The author tries to explore the above issues from the perspective of modern pharmacology. A monarch medicine is a medicine that treats the main disease or the main disease and plays a major therapeutic role. Because it is designed for the main contradiction and plays a decisive therapeutic role, it occupies a dominant position in all parties. Monarch’s performance rules and affect the entire prescription