在胆石病人和动物模型的胆汁中已识别许多可能的成核因子,如粘液、钙和胆红素。最近的研究提示胆汁内总蛋白可能是一种以前未被认识的成核因子。作者检验胆汁总蛋白增加先于胆固醇结石形成的假设。 将成年雄性草原犬鼠分为对照组(N=22)和0.4％胆固醇饲料组(N=18),最长饲养18周。饲料中所含胆固醇为蛋黄粉(0.2％胆固 Many possible nucleating factors, such as mucus, calcium and bilirubin, have been identified in bile of gallstone patients and animal models. Recent studies suggest that total bile protein may be a previously unknown nuclear factor. The authors tested the hypothesis that total bile protein increases prior to cholesterol calculus formation. Adult male prairie dogs were divided into control group (N = 22) and 0.4% cholesterol diet group (N = 18) for up to 18 weeks. The cholesterol contained in the feed is egg yolk powder (0.2% cholesterol