目的探讨系统性红斑狼疮(SLE)继发干燥综合征(SS)患者的临床及实验特征,并与SLE及原发性干燥综合征(pSS)患者进行比较,了解SLE继发SS患者的临床及实验室特点。方法入选SLE患者208例,参照SS诊断标准,将满足SS及SLE诊断标准的患者(SLE-SS)与不伴SS的SLE患者(单纯SLE)及pSS患者进行比较。结果在208例SLE患者中,有26例(12.5%)满足SS的诊断标准且均为继发。与单纯SLE患者比较,SLE-SS患者年龄大,关节炎、肺部受累发生率高,高球蛋白血症、CRP、抗U1snRNP、抗SSA52、抗SSA60抗体阳性率高。与pSS患者相比,SLE-SS患者年龄小,关节炎、雷诺现象、皮肤黏膜病变发生率高。白细胞降低、中性粒细胞降低、血小板降低、低补体血症阳性率高,SmD1、dsDNA、SSA60阳性率高。结论 SLE-SS具有与SLE及pSS不同的临床及实验室特征。 Objective To investigate the clinical and experimental features of patients with systemic lupus erythematosus (SLE) secondary to Sjögren syndrome (SS) and compare them with patients with SLE and primary Sjogren’s syndrome (SS) Laboratory characteristics. Methods A total of 208 patients with SLE were enrolled in this study. According to SS diagnostic criteria, patients with SLE and SS without SLE were compared with those with SLE and SS without SLE. Results Of 208 SLE patients, 26 (12.5%) met the diagnostic criteria of SS and were all secondary. Compared with simple SLE patients, patients with SLE-SS were older, had higher rates of arthritis and lung involvement, high positive rates of serum globulin, CRP, anti-U1snRNP, anti-SSA52 and anti-SSA60 antibodies. Compared with patients with pSS, SLE-SS patients with younger age, arthritis, Raynaud’s phenomenon, high incidence of mucocutaneous lesions. Leukopenia, neutropenia, thrombocytopenia, low positive rate of hyperlipidemia, SmD1, dsDNA, SSA60-positive rate. Conclusions SLE-SS has different clinical and laboratory features than SLE and pSS.