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缺锌可引起各种免疫功能减退,其程度可能与锌缺乏程度有关。肠源性肢体皮炎病人接受无锌全静脉营养及使用青霉胺所致的严重缺锌,可引起的胸腺萎短,淋巴细胞和选择性T_4+辅助细胞减少,淋巴细胞促分裂增殖反应减缓,免疫无应答以及NK细胞活力和胸腺激素活性降低等。而酒精中毒性肝病、吸收不良综合症、尿毒症和镰刀细胞贫血(SCD)的中度缺锌,可导致免疫无应答,NK细胞活力下降,却无胸腺萎缩和淋巴细胞减少的现象。
Zinc deficiency can cause a variety of immune dysfunction, the extent may be related to the degree of zinc deficiency. Gut-derived limb dermatitis patients receiving zinc-free whole-vein nutrition and severe zinc deficiency caused by penicillamine could cause atrophy of thymus, decrease of lymphocyte and selective T 4 + helper cells, slow down of lymphocyte mitosis and proliferation, immunity No response and NK cell activity and thymus hormone activity decreased. Alcohol-induced liver disease, malabsorption syndrome, uremia, and mild zinc deficiency in scytal cell anemia (SCD) can lead to immune non-response, NK cell viability decreased, but no thymic atrophy and lymphopenia phenomenon.