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英国伦敦消息:一项对照、前瞻性研究证实,青少年在急性病毒感染后胰岛素自身抗体(IAA)大量增加,这表明病毒可能在幼年型糖尿病发病机理中起一定作用,IAA和胰岛细胞抗体(ICA)是新诊断的糖尿病病人及其家属的血清学标志。此项研究包括71名儿童(平均年龄13岁),患流行性腮腺炎、风疹、水痘或麻疹。在患病期间进行检查,并随访6个月,分别在第2、第6和第26周采取血样。对照组包括61名近期无感染的非糖尿病儿童。大多数感染儿童在诊断8周内产生IAA,其中IgM—IAA比IgG-IAA更为常见。在71名感染儿童中,检测了51人的IgM-IAA,尤其
LONDON, UNITED KINGDOM: A controlled, prospective study confirms a substantial increase in insulin autoantibodies (IAA) in adolescents after acute viral infection, suggesting that the virus may play a role in the pathogenesis of juvenile diabetes and that IAA and islet cell antibodies (ICA ) Is a serological marker of newly diagnosed diabetic patients and their families. The study included 71 children (mean age 13 years) with mumps, rubella, chickenpox or measles. During the illness period, the patients were followed up for 6 months and blood samples were taken at weeks 2, 6 and 26, respectively. The control group included 61 recent non-infected non-diabetic children. Most infected children produce IAA within 8 weeks of diagnosis, with IgM-IAA being more common than IgG-IAA. Among 71 infected children, 51 human IgM-IAA were detected, in particular