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近年来我国率先在世界上采用中药砒霜(主要成分三氧化二砷)治疗急性早幼粒细胞白血病的成功,为恶性的治疗提供了一条新的途径。砷剂对多种血液肿瘤与非血液肿瘤具有杀伤作用,其作用机制涉及诱导细胞凋亡与抑制细胞增殖等,与含巯基(-SH)物质结合以及通过影响线粒体跨膜电位(△m)进而释放一些凋亡效应分子是其抗癌作用的分子基础。对实体瘤的临床效果及其给药途径、剂量、安全性等有待进一步评价。
In recent years, our country took the lead in adopting the Chinese medicine arsenic cream (the main component of arsenic trioxide) in the world to treat the success of acute promyelocytic leukemia, which provides a new way for malignant treatment. Arsenic has a killing effect on a variety of hematological and non-hematological malignancies, and its mechanism of action involves the induction of apoptosis and inhibition of cell proliferation, binding to sulfhydryl (-SH) -containing substances, and by affecting mitochondrial transmembrane potential (Δm) The release of some apoptosis effector molecules is the molecular basis of their anti-cancer effects. The clinical efficacy of solid tumors and its route of administration, dosage, safety and so need further evaluation.