2-氧烷基磷酸酯(Ⅰ)之钠盐能与醛或酮进行Horner-Emmons-Wittig缩合反应,生成α,β-不饱和酮(Ⅱ),此反应能在温和条件下进行,产物之双键为反式,故在合成结构复杂的α,β-不饱和酮时很有用。我们在合成含不同下侧链前列腺素改造物(Ⅲ)时,常需要相应的磷酸酯(Ⅰ)。 The sodium salt of 2-oxoalkylphosphates (I) can undergo Horner-Emmons-Wittig condensation with aldehydes or ketones to form α, β-unsaturated ketones (II) which can be carried out under mild conditions. The product of The double bond is trans, so useful in the synthesis of complex α, β-unsaturated ketones. We often need the corresponding phosphates (I) when synthesizing prostanoids (III) with different lower side chains.