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目的探讨大剂量富露施(N-乙酰半胱氨酸)对尘肺患者肺功能的影响。方法将确诊的尘肺患者48例,随机分为两组,常规治疗强的松为对照组,另一组加用大剂量富露施(N-乙酰半胱氨酸)为观察组(600mg/次,3次/d,口服)进行6个月观察治疗。观察其临床症状减轻,活动力增强,血气分析、肺功能PaO2、VC%、DLCO%等指标均改善。结果观察组疗效显著其缓解率达66.7%;单用强的松对照组缓解率为37.5%,两组差异统计学意义P<0.05。结论对于尘肺患者应用强的松标准治疗基础上加用大剂量富露施(N-乙酰半胱氨酸)可显著的延缓肺功能的主要指标,笔者认为有临床意义。
Objective To investigate the effects of high-dose prostaglandin E (N-acetylcysteine) on pulmonary function in patients with pneumoconiosis. Methods Forty-eight patients with definite pneumoconiosis were randomly divided into two groups: prednisone was used as the control group, and the other group was treated with high-dose prosamide (N-acetylcysteine) as observation group (600mg / time , 3 times / d, orally) for 6 months observation and treatment. Observed the clinical symptoms, activity increased, blood gas analysis, pulmonary function PaO2, VC%, DLCO% and other indicators were improved. Results The observation group had a significant response rate of 66.7%. The prednisone alone group had a response rate of 37.5%. The difference between the two groups was statistically significant (P <0.05). Conclusions For the patients with pneumoconiosis, the predominant standard of prednisone should be based on the use of large doses of chlorhexidine (N-acetylcysteine) can significantly delay the main indicators of lung function, I think there is clinical significance.