目的:通过比较柴胡醋制前后对抑郁症小鼠脑内DA、NE的影响,探讨柴胡疏肝解郁作用机制。方法:ELISA法测定抑郁症模型小鼠脑内DA和NE的含量。结果:柴胡可使抑郁症小鼠脑内NE、DA含量明显增加,且醋柴胡作用强于生柴胡,纳入复方逍遥散后,可增强此作用。结论:柴胡与醋柴胡均具有抗抑郁作用,作用机理可能与其增加脑内单胺类递质NE、DA含量有关。 Objective: To compare the effect of Chaihu Shu vinegar on DA and NE in the brain of depression mice and to explore the mechanism of Chaihu Shugan Jieyu. Methods: The contents of DA and NE in the brain of depression model mice were determined by ELISA. Results: Bupleurum could depress the content of NE and DA in the brain of depressive mice, and the effect of Bupleurum chinense was stronger than that of Bupleurum chinense. Conclusion: Both Bupleurum chinense and Bupleurum chinense have antidepressant effects, which may be related to the increase of monoamine neurotransmitters NE and DA in the brain.