人们已经发现孕期患类风湿性关节炎、Grave病和桥本氏甲状腺炎的妇女,病情常有所缓解.在患自身免疫性甲状腺疾病的孕妇血清中,抗甲状腺球蛋白和抗微粒体抗体水平下降或长效甲状腺刺激素保护因子的活性减低.实验已证实孕期孕激素、封闭抗体和妊娠相关蛋白的存在抑制着抗胎儿的同种排斥反应.其中α_2糖蛋白(α_2-PAG)是近年来从孕妇血清中提出的一种具有免疫抑制作用的高分子糖蛋白,在正常血清中含量很少.有人报导患类风 It has been found that women with rheumatoid arthritis, Grave’s disease and Hashimoto’s thyroiditis during pregnancy are often relieved. In pregnant women with autoimmune thyroid disease serum anti-thyroglobulin and anti-microsomal antibodies levels Decreased or long-acting thyroid stimulating hormone protective factor activity reduced.Experiment has confirmed that the pregnancy progesterone, blocking antibodies and pregnancy-related protein inhibit the anti-rejection of the fetus all the same.Among them, An immunosuppressive macromolecular glycoprotein proposed from the serum of pregnant women has very little content in normal serum.