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目的:探讨清脂胶囊联合阿托伐他汀钙片治疗高脂血症的临床疗效及对血管内皮功能的影响。方法:130例高脂血症患者随机分为观察和对照组各65例。对照组采用阿托伐他汀钙片,20 mg/次,1次/d,口服。观察组在对照组治疗的基础上加用清脂胶囊,4粒/次,3次/d,口服。两组均治疗8周。测定治疗前后总胆固醇(TC),甘油三酯(TG),低密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C),载脂蛋白A(ApoA)及载脂蛋白B(ApoB);检测一氧化氮(NO)及血管性血友病因子(vWF)水平。结果:治疗后观察组TC、TG,LDL-C及ApoB100水平均低于对照组(P<0.05,P<0.01);HDL-C及ApoA1水平高于对照组(P<0.05);治疗后观察组总有效率93.85%,优于对照组的81.54%(P<0.05);治疗后观察组vWF水平低于对照组,NO水平高于对照组(P<0.01)。结论:清脂胶囊联合阿托伐他汀钙片能改善患者血脂水平,提高临床疗效,并对血管内皮功能有保护作用。
Objective: To investigate the clinical efficacy of Qingzhi Capsule combined with atorvastatin calcium in the treatment of hyperlipidemia and its effect on endothelial function. Methods: 130 cases of hyperlipidemia were randomly divided into observation and control group of 65 cases. Control group with atorvastatin calcium tablets, 20 mg / time, 1 / d, orally. Observation group in the control group based on the treatment plus Qingzhi capsule, 4 capsules / time, 3 times / d, orally. Both groups were treated for 8 weeks. The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), apolipoprotein A (ApoA) and apolipoprotein B (ApoB). Levels of nitric oxide (NO) and von Willebrand factor (vWF) were measured. Results: The levels of TC, TG, LDL-C and ApoB100 in the observation group were lower than those in the control group (P <0.05, P <0.01), while the levels of HDL-C and ApoA1 in the observation group were higher than those in the control group The total effective rate was 93.85%, which was higher than that of the control group (81.54%, P <0.05). After treatment, the vWF level in the observation group was lower than that in the control group, and the NO level was higher than that in the control group (P <0.01). Conclusion: Qingzhi capsule combined with atorvastatin calcium tablets can improve blood lipid levels, improve clinical efficacy, and vascular endothelial function have a protective effect.