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目的观察中西医结合治疗膝骨关节炎(KOA)的临床疗效。方法纳入2012年1月-2015年6月诊治的180例KOA患者,随机分为3组,中医组(A组,n=60)针灸配合特定电磁波治疗器照射治疗;西医组(B组,n=60)口服盐酸氨基葡萄糖片、膝关节腔内注射玻璃酸钠;中西医结合组(C组,n=60)为在A组的方法上同时加用B组的治疗方法;疗程均为6周。分别于治疗前和治疗后2周末、治疗结束时及治疗结束后5个月末,评定西安大略和麦克马斯特大学骨关节炎指数(WOMAC评分)和总有效率。结果治疗后各组WOMAC评分差异有统计学意义(P<0.05);总有效率A组78.33%,B组83.33%,C组91.67%;C组与A组、C组与B组比较总有效率,差异均有统计学意义(P<0.05),A、B组总有效率比较差异亦具有统计意义(P<0.05)。不良反应A组2例,B组2例,C组2例;均较轻微,无严重不良事件发生。结论中医、西医治疗KOA均安全、有效,联合应用时,疗效进一步增强,不良反应未增加。
Objective To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of knee osteoarthritis (KOA). Methods One hundred and eighty patients with KOA diagnosed and treated from January 2012 to June 2015 were randomly divided into three groups. The Acupuncture group (A group, n = 60) was treated with acupuncture and Moxibustion with special electromagnetic wave therapy device. The western medicine group (B group, n = 60) oral administration of glucosamine hydrochloride tablets, knee intra-articular injection of sodium hyaluronate; Integrative Medicine group (C group, n = 60) for the treatment of group A at the same time with the B group; week. The osteoarthritis index (WOMAC score) and total effective rate in Western Ontario and McMaster University were assessed before treatment and 2 weeks after treatment, at the end of treatment, and 5 months after the end of treatment, respectively. Results The WOMAC score of each group after treatment was significantly different (P <0.05). The total effective rate was 78.33% in A group, 83.33% in B group and 91.67% in C group. There was a significant difference between C group and A group, C group and B group (P <0.05). The total effective rate in groups A and B was also statistically significant (P <0.05). Adverse reactions in 2 cases in group A, 2 cases in group B, 2 cases in group C; all were mild and no serious adverse events occurred. Conclusion Chinese medicine and Western medicine treatment of KOA are safe, effective, combined application, the effect was further enhanced, adverse reactions did not increase.